Articles

Stronger Candidates May Live Beyond the Known Scaffold. Case of QTX3034.

The winning scaffold is not necessarily where the most interesting chemistry ends. A better search may start by moving away from it into structurally different, property-matched chemical space. QTX3034 is a good example. Around this KRAS G12D program the public record shows several promising mechanistic and chemical branches. Only one remained visible as the surviving development path. More...